Contribution of Staphylococcal Enterotoxin B toStaphylococcus aureusSystemic Infection
| Autor: | Gordon Y. C. Cheung, Michael Otto, Justin S. Bae, Lei He, Govindarajan Rajagopalan, Huiying Lv, Emilie L. Fisher, Min Li, Ryan Liu, Fei Da |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Virulence Toxin hemic and immune systems chemical and pharmacologic phenomena Human pathogen Enterotoxin Staphylococcal Infections Biology medicine.disease_cause medicine.disease Methicillin-resistant Staphylococcus aureus biological factors Microbiology Major Articles and Brief Reports Enterotoxins Mice Infectious Diseases Staphylococcus aureus medicine Superantigen Animals Immunology and Allergy Cytokine storm |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiaa584 |
| Popis: | Staphylococcal enterotoxin B (SEB), which is produced by the major human pathogen, Staphylococcus aureus, represents a powerful superantigenic toxin and is considered a bioweapon. However, the contribution of SEB to S. aureus pathogenesis has never been directly demonstrated with genetically defined mutants in clinically relevant strains. Many isolates of the predominant Asian community-associated methicillin-resistant S. aureus lineage sequence type (ST) 59 harbor seb, implying a significant role of SEB in the observed hypervirulence of this lineage. We created an isogenic seb mutant in a representative ST59 isolate and assessed its virulence potential in mouse infection models. We detected a significant contribution of seb to systemic ST59 infection that was associated with a cytokine storm. Our results directly demonstrate that seb contributes to S. aureus pathogenesis, suggesting the value of including SEB as a target in multipronged antistaphylococcal drug development strategies. Furthermore, they indicate that seb contributes to fatal exacerbation of community-associated methicillin-resistant S. aureus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|