Consequences of hemophagocytic lymphohistiocytosis-like cytokine release syndrome toxicities and concurrent bacteremia
| Autor: | Jon Inglefield, Javed Khan, Nirali N. Shah, Katherine E. Masih, Veronique Nussenblatt, Lauren Little, Maura Manion, Amanda K. Ombrello, Zahin Islam, Haneen Shalabi, John A. Ligon, Bonnie Yates |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
T-Lymphocytes Antigens CD19 Inflammation Bacteremia Systemic inflammation Immunotherapy Adoptive CD19 Lymphohistiocytosis Hemophagocytic Article hemic and lymphatic diseases otorhinolaryngologic diseases Medicine Humans Hemophagocytic lymphohistiocytosis Receptors Chimeric Antigen biology business.industry Hematology Immunotherapy medicine.disease Clinical trial Cytokine release syndrome Oncology Pediatrics Perinatology and Child Health Immunology biology.protein medicine.symptom business Cytokine Release Syndrome |
| Zdroj: | Pediatr Blood Cancer |
| ISSN: | 1545-5017 |
| Popis: | Serious bacterial infections (SBI) can lead to devastating complications with CD19 CAR T cells and cytokine release syndrome (CRS). Little is known about consequences of and risk factors for SBI with novel CAR T-cell constructs or with CRS complicated by HLH-like toxicities. We report on three patients with B-cell acute lymphoblastic leukemia treated with CD22 CAR T cells who developed SBI and CRS-associated HLH. Serum cytokine profiling revealed sustained elevations well beyond CRS resolution, suggesting ongoing systemic inflammation. Heightened inflammatory states converging with SBI contribute to poor outcomes, and recognition and prevention of extended inflammation may be needed to improve outcomes. |
| Databáze: | OpenAIRE |
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