Cost-effectiveness of a randomised trial of physical activity in Alzheimer's disease:A secondary analysis exploring patient and proxy-reported health-related quality of life measures in Denmark
| Autor: | Elizaveta Sopina, Jan Sørensen, Steen G. Hasselbalch, Gunhild Waldemar, Nina Beyer |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Cost effectiveness Visual analogue scale Cost-Benefit Analysis Denmark Psychological intervention Disease Proxy (climate) 03 medical and health sciences Health Economics 0302 clinical medicine Caregivers/psychology quality of life measurement Alzheimer Disease Informed consent Respite care Medicine Aerobic exercise Humans 030212 general & internal medicine Alzheimer Disease/economics cost-effectiveness Exercise caregiver Aged Pain Measurement Aged 80 and over Psychiatric Status Rating Scales business.industry Research 030503 health policy & services alzheimer’s disease General Medicine Middle Aged Logistic Models Caregivers Physical therapy Linear Models Quality of Life Female Quality-Adjusted Life Years 0305 other medical science business |
| Zdroj: | Sopina, E, Sørensen, J, Beyer, N, Hasselbalch, S G & Waldemar, G 2017, ' Cost-effectiveness of a randomised trial of physical activity in Alzheimer's disease : A secondary analysis exploring patient and proxy-reported health-related quality of life measures in Denmark ', BMJ Open, vol. 7, e015217 . https://doi.org/10.1136/bmjopen-2016-015217 Sopina, E, Sørensen, J, Beyer, N, Hasselbalch, S G & Waldemar, G 2017, ' Cost-effectiveness of a randomised trial of physical activity in Alzheimer's disease : a secondary analysis exploring patient and proxy-reported health-related quality of life measures in Denmark ', B M J Open, vol. 7, no. 6, e015217 . https://doi.org/10.1136/bmjopen-2016-015217 BMJ Open |
| DOI: | 10.1136/bmjopen-2016-015217 |
| Popis: | ObjectivesTo explore the cost-effectiveness of a supervised moderate-to-high intensity aerobic exercise programme in people diagnosed with Alzheimer’s disease (AD) and estimate incremental cost-effectiveness ratios (ICER) using participant-reported and proxy-reported measures of health-related quality of life (HRQoL)DesignA cost-effectiveness analysis of economic and HRQoL data from a randomised trial delivered over 16 weeks.SettingMemory clinics in Denmark.Participants200 individuals with mild AD aged 50–90 years gave informed consent to participate in the study. Participants were randomised to control or intervention group.InterventionsControl group received treatment as usual. The intervention group performed 1 hour of supervised moderate-to-high intensity aerobic exercise three times weekly for 16 weeks.Primary and secondary outcomes measuresDifferent physical, functional and health measures were obtained at inclusion (baseline) and 4 and 16 weeks after. HRQoL (EuroQol-5 Dimensions-5 Levels/EQ-Visual Analogue Scale) was reported by the participants and the primary caregivers as proxy respondents. Differences in HRQOL as reported by the participant and caregiver were explored as were different values of caregiver time with respite from care tasks.ResultsThe intervention cost was estimated at €608 and €496 per participant, with and without transport cost, respectively. Participants and caregivers in the intervention group reported a small, positive non-significant improvement in EQ-5D-5L and EQ-VAS after 16 weeks. The ICER was estimated at €72 000/quality-adjusted life year using participant-reported outcomes and €87000 using caregiver-reported outcomes.ConclusionsThe findings suggest that the exercise intervention is unlikely to be cost-effective within the commonly applied threshold values. The cost of the intervention might be offset by potential savings from reduction in use of health and social care.Trial registration numberhttps://clinicaltrials.gov/ct2/show/NCT01681602. |
| Databáze: | OpenAIRE |
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