Auditory circuit in the Drosophila brain
| Autor: | Barry J. Dickson, Ann-Shyn Chiang, Jason Sih-Yu Lai, Shih-Jie Lo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Neurons
Protocerebrum 0303 health sciences Auditory Pathways Multidisciplinary biology Biological Sciences Commissure biology.organism_classification 03 medical and health sciences 0302 clinical medicine Biological neural network Animals GABAergic Drosophila Drosophila (subgenus) Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Proceedings of the National Academy of Sciences |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1117307109 |
| Popis: | Most animals exhibit innate auditory behaviors driven by genetically hardwired neural circuits. In Drosophila , acoustic information is relayed by Johnston organ neurons from the antenna to the antennal mechanosensory and motor center (AMMC) in the brain. Here, by using structural connectivity analysis, we identified five distinct types of auditory projection neurons (PNs) interconnecting the AMMC, inferior ventrolateral protocerebrum (IVLP), and ventrolateral protocerebrum (VLP) regions of the central brain. These auditory PNs are also functionally distinct; AMMC-B1a, AMMC-B1b, and AMMC-A2 neurons differ in their responses to sound (i.e., they are narrowly tuned or broadly tuned); one type of audioresponsive IVLP commissural PN connecting the two hemispheres is GABAergic; and one type of IVLP-VLP PN acts as a generalist responding to all tested audio frequencies. Our findings delineate an auditory processing pathway involving AMMC→IVLP→VLP in the Drosophila brain. |
| Databáze: | OpenAIRE |
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