Oral squamous cell carcinoma in ad libitum-fed and food-restricted Brown-Norway rats
| Autor: | D L Greenman, Ralph L. Kodell, A Turturro, J D Thurman |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Biology Toxicology 030226 pharmacology & pharmacy Pathology and Forensic Medicine 0403 veterinary science Rodent Diseases 03 medical and health sciences Eating 0302 clinical medicine Internal medicine Rats Inbred BN Carcinoma medicine Animals Basal cell Molecular Biology Mouth neoplasm Incidence (epidemiology) Incidence digestive oral and skin physiology Significant difference BROWN NORWAY 04 agricultural and veterinary sciences Cell Biology medicine.disease Animal Feed Rats stomatognathic diseases Endocrinology Epidermoid carcinoma Cohort Carcinoma Squamous Cell Female Mouth Neoplasms Food Deprivation |
| Zdroj: | Toxicologic pathology. 25(2) |
| ISSN: | 0192-6233 |
| Popis: | A high incidence of oral squamous cell carcinoma was present in male and female Brown-Norway rats fed ad libitum or food-restricted dietary formulations. One hundred eighty-nine rats were examined from 4 dietary treatment groups: male ad libitum, male food-restricted, female ad libitum, and female food-restricted. The ad libitum treatment groups for both males and females had significantly more cases of oral squamous cell carcinoma than cohort food-restricted groups. In ad libitum rats, 10 of 47 (21%) males and 15 of 47 (32%) females had oral squamous cell carcinoma, whereas only 4 of 47 (9%) males and 5 of 48 (10%) females in the food-restricted groups were similarly affected. The food-restricted rats lived significantly longer than ad libitum cohorts, so the higher incidence of squamous cell carcinoma was not dependent on extended lifespans. In addition to the dietary influence, a significant difference in oral squamous cell carcinoma incidence occurred between various familial lines. Family lines having representatives in both ad libitum and food-restricted groups had lower oral squamous cell carcinoma incidences in the food-restricted group whether comparing affected litters or individuals. Results suggest that the incidence of oral squamous cell carcinoma in our colony of Brown-Norway rats can be influenced by both the dietary treatment group and genetic predilection within certain pedigrees. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|