Reprogramming of astrocytes to neuronal precursor cells using lentiviral vectors for the potential treatment of CNS injuries

Autor: Schnaubelt, A, Zhou, X, Zheng, G, Wang, H, Hatami, M, Skutella, T, Unterberg, AW, Zweckberger, K, Younsi, A
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV018 /20220525/
DOI: 10.3205/22dgnc019
Popis: Objective: The main drivers for persisting neurological symptoms after CNS injury are secondary pathophysiological changes, such as astrogliosis and glial scarring, inhibiting axonal regeneration and functional recovery. Thus, targeting the astroglial scar has become a promising experimental treatment [for full text, please go to the a.m. URL]
Databáze: OpenAIRE