Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia

Autor: Haruna Saito, Yasuhiro Wada, Yasuyoshi Watanabe, Takato Abe, Itsuki Hasegawa, Jun Takeuchi, Takayuki Kikukawa, Suzuka Ataka, Yoshiaki Itoh, Toshikazu Mino, Joji Kawabe
Rok vydání: 2018
Předmět:
Male
Amyloid
medicine.medical_specialty
Neurology
Perfusion Imaging
Dermatology
Neuropsychological Tests
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
mental disorders
medicine
Humans
Dementia
Cognitive Dysfunction
Aged
Retrospective Studies
Neuroradiology
Tomography
Emission-Computed
Single-Photon
Aniline Compounds
medicine.diagnostic_test
business.industry
Brain
Cognition
General Medicine
Prognosis
medicine.disease
Thiazoles
Psychiatry and Mental health
Cerebral blood flow
Positron emission tomography
Positron-Emission Tomography
Disease Progression
Cardiology
Female
Neurology (clinical)
Neurosurgery
Radiopharmaceuticals
business
Perfusion
030217 neurology & neurosurgery
Follow-Up Studies
Phenanthrolines
Zdroj: Neurological Sciences. 39:1597-1602
ISSN: 1590-3478
1590-1874
DOI: 10.1007/s10072-018-3477-0
Popis: Mild cognitive impairment (MCI) can include the transition from a normal state to dementia. To explore biomarkers for the development of dementia, we performed an 18-month follow-up study in 28 patients with amnestic MCI. Amyloid deposition was examined using PiB PET, and cerebral blood flow (CBF) was examined using SPECT. Cognitive function was periodically assessed. The rate of conversion to dementia was higher in the PiB-positive/equivocal group (74%) than in the PiB-negative group (33%) (p = 0.041). Perfusion SPECT was performed in 16 patients. MCI patients with an AD-characteristic pattern of reduced CBF had a higher PiB-positive/equivocal rate (82%) than those with a non-AD pattern (20%) (p = 0.018), and patients with an AD pattern had a higher conversion rate (82%) than those with a non-AD pattern (40%) (p = 0.094). Clinically, all PiB-positive converters were diagnosed as having Alzheimer's disease (AD), whereas PiB-negative converters were thought to have some form of dementia other than AD. Amyloid PET is useful for predicting conversion to AD in MCI patients. A pattern analysis of perfusion SPECT findings might also be helpful for predicting conversion to AD, but with a lower specificity.
Databáze: OpenAIRE
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