Corticosteroid Therapy Might be Associated with the Development of Coronary Aneurysm in Children with Kawasaki Disease
Autor: | Ling-Ling Gao, Zhong-Dong Du, Chun-Na Zhao |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Male
medicine.medical_specialty Adolescent Corticosteroid Therapy lcsh:Medicine 030204 cardiovascular system & hematology Mucocutaneous Lymph Node Syndrome Logistic regression 03 medical and health sciences 0302 clinical medicine Aneurysm Risk Factors Adrenal Cortex Hormones Internal medicine Coronary Artery Lesions medicine Humans 030212 general & internal medicine Risk factor Kawasaki Disease Retrospective Studies business.industry Incidence (epidemiology) lcsh:R Coronary Aneurysm Infant Retrospective cohort study General Medicine medicine.disease Surgery Coronary Artery Aneurysms medicine.anatomical_structure Logistic Models Child Preschool Kawasaki disease Original Article Female Complication business Artery |
Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 129, Iss 8, Pp 922-928 (2016) |
ISSN: | 0366-6999 |
Popis: | Background: Coronary artery lesions (CALs) are known to be the main complication in children with Kawasaki disease (KD). Instead of intravenous immunoglobulin (IVIG), corticosteroid therapy has been accepted to be used for children with KD who are unresponsive to IVIG. This study aimed to evaluate risk factors for CALs in children with KD. Methods: We retrospectively reviewed the clinical records of 2331 children with KD from January 2005 to December 2014. To identify the independent risk factors for CALs, multivariable logistic regression models were constructed using significant variables identified from univariate logistic regression analysis. Results: The incidence of CALs was 36.0% (840 of 2331), including 625 (26.8%) coronary artery dilations and 215 (9.2%) coronary artery aneurysms (CAAs). Multivariable logistic regression analysis identified that male, incomplete KD, longer fever duration, and C-reactive protein (CRP) >100 mg/L were independent risk factors for coronary artery dilatations. On the other hand, male, incomplete KD, longer fever duration, prolonged days of illness at the initial treatment, corticosteroid therapy, sodium ≤133 mmol/L, and albumin 100 mg/L, and corticosteroid therapy. Corticosteroid therapy was an independent risk factor for CAAs and giant CAAs. Thus, corticosteroids should be used with caution in the treatment of KD with the risk for CALs. |
Databáze: | OpenAIRE |
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