Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

Autor:	Isidoro González-Álvaro, Jesús Tornero, Luis Rodriguez-Rodriguez, A. Olivé, Benjamín Fernández-Gutiérrez, Alba Erra, Núria Palau, Francisco J. Blanco, Inmaculada Ureña-Garnica, Juan D. Cañete, María López-Lasanta, Arnald Alonso, Joan Maymó, Raül Tortosa, Antonio Julià, Hèctor Corominas, Mercedes Alperi-López, Gabriela Ávila, Miriam Almirall, Ana M. Ortiz, Sara Marsal
Přispěvatelé:	[Lopez-Lasanta,M, Julià,A, Palau,N, Avila,G, Alonso,A, Tortosa,R, Marsal,S] Vall d’Hebron Hospital Research Institute, Rheumatology Research Group, Barcelona, Spain. [Maymó,J, Almirall,A] Rheumatology Department, Hospital del Mar, Barcelona, Spain. [Fernández-Gutiérrez,F] Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain. [Ureña-Garnica,I] UGC Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. [Blanco,FJ] Rheumatology Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain. [Cañete,JD] Rheumatology Department, Hospital Clínic de Barcelona, Barcelona, Spain. [Alperi-López,M] Rheumatology Department, Hospital Universitario Central de Asturias, Oviedo, Spain. [Olivè,A] Rheumatology Department, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain. [Corominas,H] Rheumatology Department, Hospital Moisès Broggi, L´ Hospitalet de Llobregat, Barcelona, Spain. [Tornero,J] Rheumatology Department, Hospital Universitario De Guadalajara, Guadalajara, Spain. [Erra,A]Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain. [Ortiz,A, Gonzalez-Alvaro,I] Rheumatology Department, Hospital Universitario La Princesa, IIS La Princesa, Madrid, Spain., This study was funded by the Spanish Ministry of Economy and Competitiveness (grant numbers PSE-010000-2006-6 and IPT-010000-2010-36).
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Linkage disequilibrium España Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis::Linear Models [Medical Subject Headings] Linkage Disequilibrium Arthritis Rheumatoid Cohort Studies Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Gene Frequency Receptors Metanálisis como asunto Medicine Immunology and Allergy Halotipos Modelos lineales Single nucleotide Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings] Predisposición genética a la enfermedad Phenomena and Processes::Genetic Phenomena::Genetic Linkage::Linkage Disequilibrium [Medical Subject Headings] Polimorfismo de nucleótido único Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis Rheumatoid [Medical Subject Headings] Articulaciones Rheumatoid arthritis Arthritis rheumatoid Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings] Alelos Research Article musculoskeletal diseases Genotype Anatomy::Musculoskeletal System::Skeleton::Joints [Medical Subject Headings] Immunology Estudios de cohortes Genetic predisposition to disease Single-nucleotide polymorphism Artritis reumatoide Polymorphism Single Nucleotide Receptores de interleucina-6 Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings] Meta-Analysis as Topic Rheumatology Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors Immunologic::Receptors Cytokine::Receptors Interleukin::Receptors Interleukin-6 [Medical Subject Headings] Genetic variation SNP Humans Genetic Predisposition to Disease Allele Polymorphism Allele frequency Alleles Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings] Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings] business.industry Interleukin-6 Haplotype Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Meta-Analysis as Topic [Medical Subject Headings] Artritis reumatoide -- Tractament medicine.disease Receptors Interleukin-6 Gene frequency Frecuencia génica Haplotypes Desequilibrio de ligamiento Spain Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] Linear Models Joints business Phenomena and Processes::Genetic Phenomena::Gene Frequency [Medical Subject Headings] Genotipo
Zdroj:	Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname RUC. Repositorio da Universidade da Coruña Arthritis Research & Therapy Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid
Popis:	This study was funded by the Spanish Ministry of Economy and Competitiveness (grant numbers PSE-010000-2006-6 and IPT-010000-2010-36) Lopez-Lasanta, M., Julià, A., Maymó, J., Fernández-Gutierrez, B., Ureña-Garnica, I., Blanco, F.J., Cañete, J.D., Alperi-López, M., Olivè, A., Corominas, H., Tornero, J., Erra, A., Almirall, M., Palau, N., Ortiz, A., Avila, G., Rodriguez-Rodriguez, L., Alonso, A., Tortosa, R., Gonzalez-Alvaro, I., Marsal, S.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd202007f6cd066130d2875bd66085a8 https://hdl.handle.net/10668/2272 Zobrazit plný text záznamu