Concussive Brain Trauma in the Mouse Results in Acute Cognitive Deficits and Sustained Impairment of Axonal Function
| Autor: | Jennifer A Creed, Alan Tessler, Douglas Paul Fox, Ann Mae DiLeonardi, Ramesh Raghupathi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Traumatic brain injury Blotting Western Action Potentials Poison control Hippocampus Axonal Transport Mice Cognition Cortex (anatomy) Concussion medicine Animals Maze Learning Brain Concussion Neurons Analysis of Variance Dentate gyrus Original Articles medicine.disease Axons Memory Short-Term medicine.anatomical_structure nervous system Anesthesia Nerve Degeneration Closed head injury Neurology (clinical) Righting reflex Cognition Disorders Psychology |
| Zdroj: | Journal of Neurotrauma. 28:547-563 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2010.1729 |
| Popis: | Concussive brain injury (CBI) accounts for approximately 75% of all brain-injured people in the United States each year and is particularly prevalent in contact sports. Concussion is the mildest form of diffuse traumatic brain injury (TBI) and results in transient cognitive dysfunction, the neuropathologic basis for which is traumatic axonal injury (TAI). To evaluate the structural and functional changes associated with concussion-induced cognitive deficits, adult mice were subjected to an impact on the intact skull over the midline suture that resulted in a brief apneic period and loss of the righting reflex. Closed head injury also resulted in an increase in the wet weight:dry weight ratio in the cortex suggestive of edema in the first 24 h, and the appearance of Fluoro-Jade-B-labeled degenerating neurons in the cortex and dentate gyrus of the hippocampus within the first 3 days post-injury. Compared to sham-injured mice, brain-injured mice exhibited significant deficits in spatial acquisition and working memory as measured using the Morris water maze over the first 3 days (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|