Hydroxylation of secondary bile acids in the perfused prairie dog liver
| Autor: | Bertram I. Cohen, Marcus A. Rothschild, Erwin H. Mosbach, J. Mongelli, Anil K. Singhal, Charles K. McSherry |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Taurochenodeoxycholic acid Rodentia Prairie dog In Vitro Techniques Hydroxylation Biochemistry Bile Acids and Salts chemistry.chemical_compound Internal medicine biology.animal medicine Animals Chromatography High Pressure Liquid Bile acid biology Organic Chemistry Deoxycholic acid Cell Biology Metabolism Taurocholic acid Perfusion Endocrinology Liver chemistry Female Chromatography Thin Layer Taurolithocholic acid Deoxycholic Acid Taurolithocholic Acid |
| Zdroj: | Lipids. 18:909-912 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/bf02534573 |
| Popis: | Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7 alpha-hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7 alpha-hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observed in prairie dog bile are due, at least in part, to active bile acid 7 alpha-hydroxylase(s) in the liver of these animals. |
| Databáze: | OpenAIRE |
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