Mutagenicity of ozonation and chlorination products from p-hydroxybenzaldehyde
| Autor: | Hideaki Kito, Hiroaki Matsuda, Youki Ose, Hisamitsu Nagase, Takahiko Sato, Katsumi Sumida |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Salmonella typhimurium
endocrine system Environmental Engineering Tetrachloroethylene chemistry.chemical_element Chloral Ether Mutagen medicine.disease_cause Gas Chromatography-Mass Spectrometry Ames test Structure-Activity Relationship chemistry.chemical_compound Biotransformation Hydrocarbons Chlorinated Chlorine medicine Animals Environmental Chemistry Organic chemistry Waste Management and Disposal Mutagenicity Tests fungi food and beverages Ketones Chromatography Ion Exchange Pollution chemistry Benzaldehydes Microsomes Liver Gas chromatography–mass spectrometry Mutagens |
| Zdroj: | The Science of The Total Environment. 103:141-149 |
| ISSN: | 0048-9697 |
| Popis: | p-Hydroxybenzaldehyde, a component of soil humic substances, was ozonated and chlorinated. The ether extract and the residue were subjected to the Ames assay; mutagenic activities were identified. The non-ionic resin CSP800 and the anion exchange resin CHPA25 were used for separation of mutagenic compounds. The compounds in the water layer were not adsorbed on CSP800 or CHPA25 and exhibited strong mutagenic activity. Mutagenic activity was reduced as the added chlorine was increased. Ether extracts were analyzed by gas chromatography-mass spectrometry (GC-MS) and chloral, 1,3-dichloro-2-propanone, 1,2,3-trichloro-1-propene, tetrachloroethylene and 1,1,1,3,3-pentachloro-2-propanone were identified as mutagenic compounds. |
| Databáze: | OpenAIRE |
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