Serum 25-hydroxyvitamin D levels in patients with Granulomatosis with Polyangiitis: association with respiratory infection
| Autor: | Mariana O. Perez, Valeria F. Caparbo, Ricardo M. Oliveira, Rosa Maria Rodrigues Pereira, Mauricio Levy-Neto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Vasculitis medicine.medical_specialty Birmingham Vasculitis Activity Score Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine Risk factor Vitamin D Disease Activity Respiratory Tract Infections Anti-neutrophil cytoplasmic antibody 030203 arthritis & rheumatology lcsh:R5-920 Respiratory tract infections business.industry Granulomatosis with Polyangiitis Respiratory infection General Medicine Middle Aged Clinical Science medicine.disease Prednisone Female Seasons Rituximab lcsh:Medicine (General) Granulomatosis with polyangiitis business Biomarkers Immunosuppressive Agents |
| Zdroj: | Clinics; v. 72 n. 12 (2017); 723-728 Clinics; Vol. 72 Núm. 12 (2017); 723-728 Clinics; Vol. 72 No. 12 (2017); 723-728 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 72, Issue: 12, Pages: 723-728, Published: DEC 2017 Clinics, Vol 72, Iss 12, Pp 723-728 |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: To determine the possible association of serum 25-hydroxyvitamin D (25OHD) levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods: winter/spring and summer/autumn. METHODS: Thirty-two granulomatosis with polyangiitis patients were evaluated in the winter/spring, and the same patients (except 5) were evaluated in summer/autumn (n=27). The 25OHD levels were measured by radioimmunoassay. Disease activity was assessed by the Birmingham Vasculitis Activity Score Modified for Wegener’s Granulomatosis (BVAS/WG) and antineutrophil cytoplasmic antibody (ANCA) positivity. Respiratory infection was defined according the Centers for Disease Control and Prevention criteria. RESULTS: 25OHD levels were lower among patients in winter/spring than in summer/autumn (32.31±13.10 vs. 38.98±10.97 ng/mL, p=0.04). Seven patients met the criteria for respiratory infection: 5 in winter/spring and 2 in summer/autumn. Patients with respiratory infection presented lower 25OHD levels than those without infection (25.15±11.70 vs. 36.73±12.08 ng/mL, p=0.02). A higher frequency of low vitamin D levels (25OHD |
| Databáze: | OpenAIRE |
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