Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy
| Autor: | Aysenur Meric, Meral Yüksel, Mine Yazici, Volkan Kahya, Orhan Gedikli, Ahmet Midi |
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| Přispěvatelé: | MERİÇ HAFIZ, Ayşenur, Maltepe Üniversitesi |
| Rok vydání: | 2011 |
| Předmět: |
Luminescence
Tympanic Membrane Antioxidant medicine.medical_treatment Drug Evaluation Preclinical Administration Oral Inflammation Antioxidants Rats Sprague-Dawley Myringotomy Vessel density KAHYA V. Meric A. YAZICI M. YUKSEL M. MIDI A. GEDIKLI O. -Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy.- The Journal of laryngology and otology cilt.125 ss.370-5 2011 Myringoplasty Pathology Punicaceae Animals Medicine Lythraceae chemistry.chemical_classification Lamina propria Reactive oxygen species Plant Extracts business.industry General Medicine Otitis Externa Rats medicine.anatomical_structure Otorhinolaryngology chemistry Anesthesia medicine.symptom Reactive Oxygen Species business Phytotherapy |
| Zdroj: | The Journal of Laryngology & Otology. 125:370-375 |
| ISSN: | 1748-5460 0022-2151 |
| DOI: | 10.1017/s002221511000263x |
| Popis: | WOS: 000289434100008 PubMed ID: 21349238 Objective: To assess the effect of pomegranate extract on acute inflammation due to myringotomy. Design: Prospective, randomised study. Subjects: Thirty Sprague-Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 mu l/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study. Results: Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01). Conclusion: Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy. |
| Databáze: | OpenAIRE |
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