A diffusion chamber technique for measuring concentrations of antibiotics in interstitial fluid
| Autor: | A. Georgopoulos, E. Schütze, G. Laber, R. Leskova, R. Kolb |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Microbiology (medical)
Diffusion chamber Pathology medicine.medical_specialty Chromatography medicine.drug_class Chemistry Antibiotics Soft tissue Clindamycin General Medicine Oxytetracycline Anti-Bacterial Agents Diffusion Dogs Infectious Diseases Membrane Interstitial fluid Ampicillin medicine Animals Ascitic Fluid Rabbits medicine.drug |
| Zdroj: | Infection. 8:58-62 |
| ISSN: | 1439-0973 0300-8126 |
| Popis: | A method for collecting soft tissue interstitial fluid in experimental animals for the measurement of antibiotic concentrations is described. Diffusion chambers with permeable membranes of 0.45 micron porosity were implanted subcutaneously for four days in order to determine simultaneous concentrations of ampicillin and clindamycin in serum and chamber fluid after perioral administration in rabbits and of oxytetracycline after intravenous injection in dogs. The results are discussed in view of findings from other investigators using different types of tissue cages. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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