Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations
| Autor: | Deborah C. Mash, Donald S. McCorquodale, Spiridon Papapetropoulos, Lucie Jean-Gilles, Jocely Gonzalez |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Parkinson's disease Hallucinations Disease Neuropathology Amygdala Cortex (anatomy) medicine Humans In patient Aged Aged 80 and over Cerebral Cortex Lewy body Parkinson Disease medicine.disease Visual Hallucination medicine.anatomical_structure Neurology Female Lewy Bodies Neurology (clinical) Geriatrics and Gerontology Psychology Neuroscience |
| Zdroj: | Parkinsonism & Related Disorders. 12:253-256 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2005.10.005 |
| Popis: | Visual hallucinations (VH) are among the most common non-motor complications of Parkinson's disease (PD). A few studies on their etiopathogenesis have suggested involvement of cortical and amygdalar areas. In order to investigate the possible association between extranigral Lewy Body (LB) distribution across cortical and amygdalar regions and the presence of VH in PD brain donors, we conducted a clinico-pathological comparison of 10 PD patients with VH vs 10 closely matched PD patients without VH. The LB burden was significantly higher across the amygdala and the frontal, temporal and parietal cortical areas in patients with VH. Although our results suggest significant extranigral involvement, the precise etiopathologic mechanisms responsible for the development of VH need further clarification. |
| Databáze: | OpenAIRE |
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