Do Serum Vascular Endothelial Growth Factor and Endostatin Reflect Radiological Radiation-Induced Changes After Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations?
| Autor: | Ki-Su Park, Sung-Kyoo Hwang, Jae-Gwang Lee, Seong-Hyun Park, Dong-Hun Kang, Jeong-Hyun Hwang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Intracranial Arteriovenous Malformations Male Vascular Endothelial Growth Factor A medicine.medical_specialty medicine.medical_treatment Urology Radiosurgery Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases parasitic diseases medicine Humans Radiation Injuries Aged business.industry Hazard ratio Arteriovenous malformation Venous blood Middle Aged medicine.disease Confidence interval Endostatins Vascular endothelial growth factor chemistry 030220 oncology & carcinogenesis Arteriovenous Fistula Biomarker (medicine) Female Surgery Neurology (clinical) Endostatin business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 126:e612-e618 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2019.02.101 |
| Popis: | Objective The aim of this study was to analyze serum levels of vascular endothelial growth factor (VEGF) and endostatin in patients with cerebral treated by stereotactic radiosurgery (SRS), and to assess their association with radiological radiation-induced changes (RICs). Methods To measure serum biomarkers, peripheral venous blood was collected before SRS and 1 week, 1 month, 3 months, and 6 months after SRS. To evaluate RICs, clinical and neuroimaging follow-up were performed concurrently every 6 months after SRS. Results Twenty-seven patients were enrolled (11 in the group with RIC, 16 in the group without RIC). Serum VEGF and endostatin levels were positively correlated (P = 0.036, r = 0.405). In the group with RIC, the median serum VEGF 6 months after SRS (58.98 pg/mL) was significantly higher than that of the group without RIC (15.17 pg/mL) (P = 0.001). Multivariate analysis revealed that higher VEGF 6 months after SRS (P = 0.001, hazard ratio, 1.032; 95% confidence interval, 1.012–1.052) and lower endostatin 1 month after SRS (P = 0.007, hazard ratio, 0.964; 95% confidence interval, 0.935–0.993) were significantly associated with RICs. Conclusions Our results show that serum levels of VEGF 6 months after SRS were higher in the group with RIC. Serum levels of VEGF 6 months and endostatin 1 month after SRS were associated with the radiological RICs. Thus, serial measurements of serum VEGF and endostatin after SRS might help predict RICs in patients with arteriovenous malformation treated by SRS. |
| Databáze: | OpenAIRE |
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