Accuracy and feasibility of piezoelectric inkjet coating technology for applications in microneedle-based transdermal delivery
| Autor: | Tobias Kosch, Leonie Hilliard, Guido Bared, Conor O'Mahony, Andrea Bocchino, Eleonora Sulas, Suzanne O'Callaghan, Anan Kenthao, A. James P. Clover, Danilo Demarchi |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Silicon chemistry.chemical_element Nanotechnology 02 engineering and technology engineering.material 030226 pharmacology & pharmacy Dispensing Coatings and Films 03 medical and health sciences 0302 clinical medicine Coating Atomic and Molecular Physics Transdermal drug delivery Electronic Stratum corneum medicine Experimental work Optical and Magnetic Materials Electrical and Electronic Engineering Diagnostics Transdermal 021001 nanoscience & nanotechnology Condensed Matter Physics Piezoelectricity Atomic and Molecular Physics and Optics bioMEMS Inkjet Microneedles Piezoelectric Electronic Optical and Magnetic Materials Surfaces Coatings and Films Surfaces medicine.anatomical_structure chemistry engineering and Optics 0210 nano-technology Layer (electronics) |
| Zdroj: | Microelectronic Engineering. 172:19-25 |
| ISSN: | 0167-9317 |
| Popis: | Coated microneedles have shown immense promise for use in transdermal delivery and diagnostics, due to their ability to painlessly breach the skin's outermost stratum corneum layer and interact with the epidermal layers immediately beneath. In this work, we use an off-the-shelf piezoelectric dispensing system to demonstrate the feasibility of depositing material directly on to steeply-sloping microneedle sidewalls, without the need for specific needle array positioning or material pretreatment. In the first instance, an analysis of deposition accuracy shows that over 95% of dispensed droplets land within 20m of the target. Through the use of sequential dispense and drying steps, 3.2nL of a model drug formulation has been deposited onto both silicon and polymeric microneedles with highly sloped (71) sidewalls; these are the steepest surfaces that have been coated to date. Finally, preliminary ex-vivo skin studies have been performed to show that the material may be successfully transferred from the needle to skin. Despite the smooth surfaces, ultrasharp tips and steep sidewalls of these structures, piezoelectric dispense techniques are clearly feasible for microneedle coating and may offer a promising alternative to conventional coating processes. Display Omitted Piezoelectric inkjet technology is used to coat silicon and polymer microneedlesNo specific sample positioning or preparation is requiredLoading of 3.2nL per needle has been achieved.Ex-vivo experimental work shows successful transfer of model drug to skinThis technique has applications in transdermal drug delivery and diagnostics. |
| Databáze: | OpenAIRE |
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