Effect of lipid extraction, adrenalectomy, and cortisol upon free radical formation by rat lung microsomes
| Autor: | Ann Ruhmann-Wennhold, Don H. Nelson |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Epinephrine Free Radicals Hydrocortisone medicine.medical_treatment chemistry.chemical_element Biochemistry Oxygen Acetone chemistry.chemical_compound Adrenochrome Endocrinology Superoxides Internal medicine Microsomes medicine Animals Free Radical Formation Lung Chromatography Superoxide Adrenalectomy Lipids Rats chemistry Microsome Female medicine.drug |
| Zdroj: | Journal of steroid biochemistry. 11(4) |
| ISSN: | 0022-4731 |
| Popis: | Free radical formation and superoxide anion production by rat lung microsomes have been determined by measurement of conversion of epinephrine to adrenochrome in vitro . There was a marked increase in Superoxide anion production by the microsomes following extraction with 10% aqueous acetone as has been seen previously following adrenalectomy in animals exposed to 100% oxygen. When the extracted lipid was added back to the extracted microsomes there was a significant reduction in the superoxide anion production similar to the reduction seen following cortisol administration to adrenalectomized animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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