The toxicity evaluation of Syzygium cumini leaves in rodents
| Autor: | Antonio Carlos Romão Borges, Selma do Nascimento Silva, Sônia Maria de Farias Freire, Maria do Socorro de Sousa Cartágenes, Iracelle Carvalho Abreu, Graciela Fernanda C. Silva, Marilene Oliveira da Rocha Borges, Adelson S. Lopes, Rachel Melo Ribeiro |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology lcsh:RS1-441 Pharmacology haematologic parameters lcsh:Pharmacy and materia medica histology Syzygium cumini (L.) Skeels Oral administration Internal medicine Medicine General Pharmacology Toxicology and Pharmaceutics Chronic toxicity Hematology biology business.industry Stomach Histology biology.organism_classification Acute toxicity medicine.anatomical_structure Syzygium acute and chronic toxicity Toxicity biochemical parameters business |
| Zdroj: | Revista Brasileira de Farmacognosia v.22 n.1 2012 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Volume: 22, Issue: 1, Pages: 102-108, Published: 30 SEP 2011 Revista Brasileira de Farmacognosia, Vol 22, Iss 1, Pp 102-108 (2012) Revista Brasileira de Farmacognosia, Vol 22, Iss 1, Pp 102-108 (2011) |
| ISSN: | 0102-695X |
| DOI: | 10.1590/s0102-695x2011005000181 |
| Popis: | This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration. |
| Databáze: | OpenAIRE |
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