Revealing anti-diabetic potency of medicinal plants of Meru Betiri National Park, Jember – Indonesia
| Autor: | Susilowati, Anak Agung Istri Ratnadewi, Jainur Rochman, Lilik Duwi Wahyudi, Ari Satia Nugraha, Tri Agus Siswoyo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
DPPH
General Chemical Engineering Flavonoid Ethyl acetate 02 engineering and technology 010402 general chemistry 01 natural sciences lcsh:Chemistry chemistry.chemical_compound medicine Potency Medicinal plants Acarbose chemistry.chemical_classification biology Traditional medicine Chemistry General Chemistry 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences lcsh:QD1-999 Antidesma bunius Lagerstroemia 0210 nano-technology medicine.drug |
| Zdroj: | Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 1831-1836 (2020) |
| ISSN: | 1878-5352 |
| Popis: | Eighteen extracts of six medicinal plants of Meru Betiri National Park (Jember, Indonesia) were studied for their anti-diabetic potency as well as their antioxidant activities (DPPH, superoxide anion and hydroxyl radical scavenging). Total phenolic and flavonoid content were also determined. Total phenols and flavonoid content increased with polarity order, from hexane, ethyl acetate to methanol extracts. Similar pattern resulted in antioxidant activity testing. Ethyl acetate extract of Antidesma bunius, methanol extract of Lagerstroemia speciosa and Lunasia amara possessed higher α-amilase inhibition compared to standard inhibitor, acarbose. Moreover, ethyl acetate extract of Antidesma bunius, methnaol extract of Arcangelisia flava, Lagerstroemia speciosa, Lunasia amara and hexane fraction of Merremia mamosa indicated higher α-glucosidase inhibition compared to standard anti-diabetic drug, acarbose. The extracts with higher phenolic and flavonoid content did not always showed higher inhibition activities α-amilase and α-glucosidase. Overall, the six medicinal plants exhibited potent sources for diabetic mellitus medication. Keywords: Antioxidant, Phenolic, Flavonoid, α-amilase inhibitor, α-glucosidase inhibtior, Anti-diabetic, Meru Betiri National Park, Indonesian medicinal plants |
| Databáze: | OpenAIRE |
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