Midbrain circuits for defensive behaviour
| Autor: | Steffen B. E. Wolff, Fabrice Chaudun, Karl Deisseroth, Maria Soledad Esposito, Charu Ramakrishnan, Jonathan P. Fadok, Silvia Arber, Milica Markovic, Lief E. Fenno, Andreas Lüthi, Cyril Herry, Paolo Botta, Philip Tovote |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Glutamic Acid Optogenetics Biology Inhibitory postsynaptic potential Midbrain Mice 03 medical and health sciences 0302 clinical medicine Escape Reaction Neural Pathways medicine Biological neural network Animals Periaqueductal Gray GABAergic Neurons Freezing Reaction Cataleptic Medulla Medulla Oblongata Multidisciplinary Central nucleus of the amygdala Neuroanatomical Tract-Tracing Techniques Neural Inhibition Amygdala Mice Inbred C57BL 030104 developmental biology Disinhibition medicine.symptom Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature |
| DOI: | 10.1038/nature17996 |
| Popis: | Survival in threatening situations depends on the selection and rapid execution of an appropriate active or passive defensive response, yet the underlying brain circuitry is not understood. Here we use circuit-based optogenetic, in vivo and in vitro electrophysiological, and neuroanatomical tracing methods to define midbrain periaqueductal grey circuits for specific defensive behaviours. We identify an inhibitory pathway from the central nucleus of the amygdala to the ventrolateral periaqueductal grey that produces freezing by disinhibition of ventrolateral periaqueductal grey excitatory outputs to pre-motor targets in the magnocellular nucleus of the medulla. In addition, we provide evidence for anatomical and functional interaction of this freezing pathway with long-range and local circuits mediating flight. Our data define the neuronal circuitry underlying the execution of freezing, an evolutionarily conserved defensive behaviour, which is expressed by many species including fish, rodents and primates. In humans, dysregulation of this 'survival circuit' has been implicated in anxiety-related disorders. |
| Databáze: | OpenAIRE |
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