Complete pathologic response rate to neoadjuvant chemotherapy increases with increasing HER2/CEP17 ratio in HER2 overexpressing breast cancer: analysis of the National Cancer Database (NCDB)
| Autor: | Apurva Mehta, Gordon Bills, Amie Jackson, Lala R. Hussain, Kathriena Greenwell, David I. Lee, Matthew Bramlage, Barbara A. Wexelman |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Databases Factual Receptor ErbB-2 medicine.medical_treatment Improved survival Breast Neoplasms computer.software_genre 03 medical and health sciences 0302 clinical medicine Text mining Breast cancer Antineoplastic Combined Chemotherapy Protocols medicine Biomarkers Tumor Pathologic Response Humans skin and connective tissue diseases Chemotherapy Database business.industry Cancer medicine.disease Prognosis Neoadjuvant Therapy 030104 developmental biology HER2/CEP17 Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Cancer cell Female business computer Chromosomes Human Pair 17 |
| Zdroj: | Breast cancer research and treatment. 181(2) |
| ISSN: | 1573-7217 |
| Popis: | HER2-positive breast cancer is an aggressive subtype of breast cancer that overexpresses human epidermal growth factor receptor 2 promoting cancer cell growth. Monoclonal antibodies targeting the HER2 receptor have improved survival for this patient population. Achieving pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) has correlated with disease-free survival in multiple trials, but we do not know why some HER2-positive tumors respond better to these therapies. We evaluated the correlation between HER2/CEP17 ratio and partial versus complete response following NAC. We evaluated whether patients with higher HER2/CEP17 ratios would have higher rates of pCR after NAC. Using the National Cancer Database (NCDB), we performed a retrospective review comparing pCR rates after NAC based on HER2 ratio between 2005 and 2014. Patients were excluded if they were HER2 negative, did not undergo NAC, or if the HER2 ratio was not recorded. Trends in percentage of pCR versus partial response were analyzed using SPSS. The NCDB included 237,118 patients with HER2 equivocal or HER2-positive breast tumors. 29,291 of these patients underwent NAC, and HER2/CEP17 ratios were recorded in 14,597 of the NAC cases. A pCR was noted in 9752 patients and 11,402 patients had a partial response. The ratios were significantly different between complete vs. partial response groups (include ratios), P |
| Databáze: | OpenAIRE |
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