Clickable Transformation of Nitriles (RCN) to Oxazolyl Sulfonyl Fluoride Warheads
| Autor: | Hua-Li Qin, Zai-Wei Zhang, Shi-Meng Wang, Wan-Yin Fang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Sulfonyl
chemistry.chemical_classification Annulation 010405 organic chemistry Organic Chemistry Ethyl ester 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Direct route chemistry.chemical_compound chemistry Physical and Theoretical Chemistry Sulfonyl fluoride Derivative (chemistry) |
| Zdroj: | Organic letters. 22(22) |
| ISSN: | 1523-7052 |
| Popis: | The protocol for simple, efficient, and mild synthesis of oxazolyl sulfonyl fluorides was developed through Rh2(OAc)4-catalyzed annulation of methyl-2-diazo-2-(fluorosulfonyl)acetate (MDF) or its ethyl ester derivative with nitriles. This practical method provides a general and direct route to a unique class of highly functionalized oxazolyl-decorated sulfonyl fluoride warheads with great potential in medicinal chemistry, chemical biology, and drug discovery. |
| Databáze: | OpenAIRE |
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