Relationship of Serum Cystatin C to Peritoneal and Renal Clearance Measures in Peritoneal Dialysis: A Cross-sectional Study
| Autor: | Michael P. Delaney, Caroline Judge, Mohammed Al Hasani, Paul E. Stevens, Edmund J. Lamb, Helen J. Stowe |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty medicine.medical_treatment Urology Renal function Kidney urologic and male genital diseases Peritoneal dialysis Cohort Studies chemistry.chemical_compound Predictive Value of Tests Internal medicine medicine Ascitic Fluid Humans Urea Cystatin C Aged Aged 80 and over Dialysis adequacy Creatinine biology business.industry Kidney metabolism Middle Aged Cystatins Cross-Sectional Studies medicine.anatomical_structure Endocrinology chemistry Research Design Linear Models biology.protein Female business Peritoneal Dialysis Biomarkers Glomerular Filtration Rate |
| Zdroj: | American Journal of Kidney Diseases. 51:278-284 |
| ISSN: | 0272-6386 |
| DOI: | 10.1053/j.ajkd.2007.08.018 |
| Popis: | Background Clinical management of peritoneal dialysis patients includes assessments of peritoneal and renal clearances of the low-molecular-weight endogenous solutes creatinine and urea. Cystatin C is a low-molecular-weight protein used as a glomerular filtration rate marker. We investigated whether serum cystatin C concentration is related to peritoneal and renal clearances of creatinine and urea. Study Design Cross-sectional study. Setting & Participants 119 patients undergoing peritoneal dialysis in a single dialysis unit. Predictor Peritoneal, renal, and total clearance of urea as Kt/V urea and creatinine as weekly creatinine clearance (C Cr ). Residual renal function (RRF) as the average of renal clearances of urea and creatinine. Outcomes & Measurements Serum concentrations of cystatin C measured by using a particle-enhanced nephelometric immunoassay. Results Serum cystatin C concentration was related inversely to RRF (Spearman rank correlation coefficient [ r s ] = −0.65; P Cr ( r s = −0.52; P urea ( r s = −0.23; P = 0.01). In a multiple regression model, weight, normalized protein catabolic rate, and RRF had independent effects on serum cystatin C concentrations. Additional multiple regression models showed that only the renal components of Kt/V urea and weekly C Cr contributed to serum cystatin C concentrations. Limitations Absence of reference GFR method. Conclusions Serum cystatin C concentrations reflect predominantly renal, not peritoneal, clearance. Serum cystatin C measurement may be a simple and practical alternative to measurement of RRF. |
| Databáze: | OpenAIRE |
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