Allopurinol Does Not Increase Free Radical Scavenging Capacity During Reperfusion in Coronary Artery Bypass Graft Patients
| Autor: | Päivi Holm, Wen-Qi Huang, Seppo Kaukinen, Ulla Kaukinen, T Sisto, Jukka Kataja, Matti Tarkka |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Free Radicals Allopurinol medicine.medical_treatment Coronary Disease Sensitivity and Specificity Xanthine law.invention Angina Intraoperative Period chemistry.chemical_compound Double-Blind Method Reference Values law Internal medicine Preoperative Care Cardiopulmonary bypass Humans Medicine Coronary Artery Bypass Infusions Intravenous Hypoxanthine Aged Probability Analysis of Variance business.industry nutritional and metabolic diseases Free Radical Scavengers Middle Aged medicine.disease Uric Acid medicine.anatomical_structure chemistry Anesthesia Reperfusion Cardiology Uric acid Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | Scandinavian Cardiovascular Journal. 34:409-414 |
| ISSN: | 1651-2006 1401-7431 |
| DOI: | 10.1080/14017430050196252 |
| Popis: | Allopurinol protects the heart against ischaemic events during coronary artery bypass grafting (CABG), possibly because of its antioxidant properties. This double-blind study was designed to investigate whether allopurinol (1 g), given before cardiopulmonary bypass and prior to the opening of cross-clamping, has an antioxidant effect in CABG patients by measuring plasma total peroxyl radical scavenging capacity.Twenty-seven patients with stabile angina were randomized into allopurinol (n = 14) or placebo (n = 13) groups.During 10 min reperfusion, plasma hypoxanthine and xanthine concentrations increased only in the allopurinol group, whereas uric acid concentrations decreased. Total peroxyl radical scavenging capacity (TRAP) decreased from the initial value at all measuring points in both groups.The reducing effect of allopurinol on free radical generation cannot be seen in TRAP values, obviously because the uric acid concentration of plasma decreases markedly. The positive clinical effects of allopurinol in CABG patients may arise from its direct oxygen free radical scavenging function. |
| Databáze: | OpenAIRE |
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