A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review
| Autor: | Kees P. van de Ven, Anne M. J. B. Smets, Raquel Davila Fajardo, Bradley R. Pieters, An Van Damme, Annelies M. C. Mavinkurve-Groothuis, Ronald R. de Krijger, Petra S. Kroon, Marc R. Lilien, Geert O. Janssens, Marry M. van den Heuvel-Eibrink, Marc H. W. A. Wijnen, Hugo A. Heij, Godelieve A.M. Tytgat, Rafal Chrzan, Jim C. H. Wilde |
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| Přispěvatelé: | Radiotherapy, CCA - Cancer Treatment and Quality of Life, Paediatric Oncology, Radiology and Nuclear Medicine, APH - Mental Health, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Long term follow up medicine.medical_treatment Enucleation Brachytherapy Renal function Kidney Neoplasms / radiotherapy Wilms Tumor / radiotherapy Nephrectomy Brachytherapy / methods 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Retrospective Studies ddc:618 business.industry Gold standard Infant Newborn Wilms tumor Wilms' tumor Perioperative medicine.disease Kidney Neoplasms Kidney Neoplasms / surgery Oncology 030220 oncology & carcinogenesis Wilms Tumor / surgery Radiology business Follow-Up Studies |
| Zdroj: | Brachytherapy, 20(2), 478-484. Elsevier Inc. Brachytherapy, Vol. 20, No 2 (2021) pp. 478-484 |
| ISSN: | 1538-4721 |
| Popis: | Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.Results (methods and case description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory. |
| Databáze: | OpenAIRE |
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