Myocarditis and carotidynia caused by Granulocyte-Colony stimulating factor administration
| Autor: | Cristina Saavedra Serrano, Arantza Barquín Garcia, Roberto Martin Huertas, Juan José Serrano Domingo, Elena Corral de la Fuente, María Fernández Abad, Noelia Martínez Jáñez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neutropenia Myocarditis Filgrastim medicine.medical_treatment Triple Negative Breast Neoplasms Chest pain Gastroenterology Carotidynia Polyethylene Glycols Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Humans Aortitis Chemotherapy business.industry Middle Aged medicine.disease Anti-Bacterial Agents Pericardial window Treatment Outcome Female Steroids medicine.symptom business Odynophagia |
| Zdroj: | Modern Rheumatology Case Reports. 4:318-323 |
| ISSN: | 2472-5625 |
| DOI: | 10.1080/24725625.2020.1754552 |
| Popis: | A 59 year-old woman was treated with adjuvant chemotherapy for triple negative breast cancer (TNBC) stage IB. She received pegfilgrastrim as secondary prophylaxis of neutropenia. After administration of pegfilgrastrim on day 11, she was hospitalised because of carotidynia and myocarditis that improved with antibiotics and steroids as an infection was suspected. Once she was recovered, another cycle of chemotherapy with pegfilgrastrim was administrated. At this time, the patient presented to our hospital with fever, odynophagia and chest pain, with diagnosis of myocarditis coupled with cardiogenic shock. She received antibiotics and steroids, advanced life support and also a pericardial window was done, with recovery of her condition. After a complete evaluation and exclusion of other possible aetiologies, we concluded that pegfilgrastrim was responsible for inducing carotidynia and myocarditis. Few cases have been published about Granulocyte-Colony stimulating factor (G-CSF) induced carotidynia and aortitis. However, this is the first reported case about G-CSF induced myocarditis and carotidynia. |
| Databáze: | OpenAIRE |
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