De novo expression of MHC class II molecules by microglial cells during acute rat renal allograft rejection
| Autor: | Veronika Grau, Birte Steiniger, Birgit Herbst |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Graft Rejection
Male Pathology medicine.medical_specialty Histology Isograft Central nervous system CD1 chemical and pharmacologic phenomena Major histocompatibility complex Pathology and Forensic Medicine Parenchyma MHC class I medicine Animals Transplantation Homologous Cerebral Cortex MHC class II biology Histocompatibility Antigens Class I Histocompatibility Antigens Class II Cell Biology Kidney Transplantation Rats Transplantation medicine.anatomical_structure Rats Inbred Lew Acute Disease biology.protein Microglia |
| Zdroj: | Cell and Tissue Research. 292:609-612 |
| ISSN: | 1432-0878 0302-766X |
| Popis: | The expression of MHC class I and class II molecules in the cerebral cortex of rats was investigated at daily intervals from day 3 to day 6 after fully allogeneic (DA--LEW) and isogeneic (LEW--LEW) kidney transplantation. MHC class II molecules were temporarily induced on the previously negative microglial cells and on the endothelia of arterioles and venules during acute rejection. On the endothelia of all brain vessels MHC class I expression was enhanced. MHC class I+ cells with microglial cell morphology were discernible within the diffusely MHC class I+ brain parenchyma. In contrast, the brain parenchyma of isograft recipients and untreated control animals did not express detectable levels of MHC molecules. In conclusion, we demonstrate that a strong immune reaction in the periphery is able to activate microglial cells in the central nervous system. |
| Databáze: | OpenAIRE |
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