Cross neutralization of SARS‐CoV‐2 omicron subvariants after repeated doses of COVID‐19 mRNA vaccines

Autor: Joanna Luczkowiak, Gonzalo Rivas, Nuria Labiod, Fátima Lasala, Marta Rolo, Jaime Lora‐Tamayo, Mikel Mancheno‐Losa, David Rial‐Crestelo, Alfredo Pérez‐Rivilla, María Dolores Folgueira, Rafael Delgado
Rok vydání: 2022
Předmět:
Zdroj: Journal of Medical Virology. 95
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.28268
Popis: We have measured the humoral response to messenger RNA (mRNA) vaccines in COVID-19 naïve and convalescent individuals. Third doses of mRNA COVID-19 vaccines induced a significant increase in potency and breadth of neutralization against SARS-CoV-2 variants of concern (VoC) including Omicron subvariants BA.1, BA.2, and BA.2.12.1, that were cross-neutralized at comparable levels and less for BA.4/5. This booster effect was especially important in naïve individuals that only after the third dose achieved a level that was comparable with that of vaccinated COVID-19 convalescents except for BA.4/5. Avidity of RBD-binding antibodies was also significantly increased in naïve individuals after the third dose, indicating an association between affinity maturation and cross neutralization of VoC. These results suggest that at least three antigenic stimuli by infection or vaccination with ancestral SARS-CoV-2 sequences are required to induce high avidity cross-neutralizing antibodies. Nevertheless, the circulation of new subvariants such as BA.4/5 with partial resistance to neutralization will have to be closely monitored and eventually consider for future vaccine developments.
Databáze: OpenAIRE
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