Glycolaldehyde-modified proteins cause adverse functional and structural aortic remodeling leading to cardiac pressure overload
| Autor: | Ivo Lambrichts, Annelies Bronckaers, Ümare Cöl, Maxim Verboven, Wouter Schurgers, Ronald B. Driesen, Lize Evens, Virginie Bito, Dorien Deluyker, Sibren Haesen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Glycation End Products
Advanced Male 0301 basic medicine lcsh:Medicine Blood Pressure 030204 cardiovascular system & hematology medicine.disease_cause Rats Sprague-Dawley 0302 clinical medicine Glycation lcsh:Science Cyclic GMP Aorta Multidisciplinary food and beverages Heart Vasodilation medicine.anatomical_structure Cardiovascular Diseases Collagen Cardiomyopathies Oxidation-Reduction Cardiac function curve medicine.medical_specialty Endothelium Cardiology Intracardiac pressure Acetaldehyde Vascular Remodeling Article Vascular remodelling in the embryo 03 medical and health sciences Internal medicine medicine.artery medicine Animals Pressure overload Superoxide Dismutase business.industry lcsh:R Acetylcholine Rats Oxidative Stress 030104 developmental biology Endocrinology Vasoconstriction lcsh:Q Endothelium Vascular business Oxidative stress |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) |
| Popis: | Growing evidence supports the role of advanced glycation end products (AGEs) in the development of diabetic vascular complications and cardiovascular diseases (CVDs). We have shown that high-molecular-weight AGEs (HMW-AGEs), present in our Western diet, impair cardiac function. Whether HMW-AGEs affect vascular function remains unknown. In this study, we aimed to investigate the impact of chronic HMW-AGEs exposure on vascular function and structure. Adult male Sprague Dawley rats were daily injected with HMW-AGEs or control solution for 6 weeks. HMW-AGEs animals showed intracardiac pressure overload, characterized by increased systolic and mean pressures. The contraction response to PE was increased in aortic rings from the HMW-AGEs group. Relaxation in response to ACh, but not SNP, was impaired by HMW-AGEs. This was associated with reduced plasma cyclic GMP levels. SOD restored ACh-induced relaxation of HMW-AGEs animals to control levels, accompanied by a reduced half-maximal effective dose (EC50). Finally, collagen deposition and intima-media thickness of the aortic vessel wall were increased with HMW-AGEs. Our data demonstrate that chronic HMW-AGEs exposure causes adverse vascular remodelling. This is characterised by disturbed vasomotor function due to increased oxidative stress and structural changes in the aorta, suggesting an important contribution of HMW-AGEs in the development of CVDs. |
| Databáze: | OpenAIRE |
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