A hybrid molecule of a GFP chromophore analogue and cholestene as a viscosity-dependent and cholesterol-responsive fluorescent sensor
| Autor: | Kenta Mori, Kazuyuki Miyashita, Yoshiko Chihara, Masahiro Ikejiri, Rino Konishi, Rina Miyagi |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry Cholesterol Vesicle Organic Chemistry Chromophore 010402 general chemistry Condensation reaction Photochemistry 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences Green fluorescent protein chemistry.chemical_compound Cholestene Molecule Physical and Theoretical Chemistry |
| Zdroj: | Organicbiomolecular chemistry. 15(33) |
| ISSN: | 1477-0539 |
| Popis: | Diarylmethylenated and cholestene (or -tane)-hybrid analogues of the GFP chromophore, namely, Ch-DAINs were successfully synthesised by a condensation reaction between methyl imidates and N-(diarylmethylene)glycinates. Among the Ch-DAINs synthesised, a diphenyl-type analogue showed viscosity-dependent and cholesterol-responsive fluorescent properties. It showed a nearly linear increase of the fluorescence emission in triglycerides and vesicles as the amount of cholesterol was increased. |
| Databáze: | OpenAIRE |
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