Effects of environmental cadmium and lead exposure on adults neighboring a discharge: Evidences of adverse health effects
| Autor: | Dorothée Dewaele, Saâd Bouhsina, Amadou Diouf, Cheikh Diop, Pirouz Shirali, Anta Tall-Dia, Mathilde Cabral, Dominique Courcot, Aminata Toure, Fabrice Cazier, Anthony Verdin, Guillaume Garçon, Mamadou Fall |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Adolescent Health Toxicology and Mutagenesis Urinary system medicine.medical_treatment Population Urine Kidney Toxicology medicine.disease_cause Antioxidants Nephrotoxicity Lipid peroxidation Young Adult chemistry.chemical_compound Internal medicine medicine Humans education Aged education.field_of_study Chemistry Environmental Exposure General Medicine Glutathione Middle Aged Pollution Senegal Oxidative Stress Waste Disposal Facilities Endocrinology Lead Female Lipid Peroxidation Reactive Oxygen Species Biomarkers Oxidative stress Cadmium |
| Zdroj: | Environmental Pollution. 206:247-255 |
| ISSN: | 0269-7491 |
| Popis: | The purpose of the study was to determine Pb and Cd concentrations in humans and to assess the effect of co-exposure to these metals on biomarkers of oxidative stress and nephrotoxicity. Blood and urine levels of Pb and Cd, oxidative stress and urinary renal biomarkers were measured in 77 subjects neighboring a discharge and 52 in the control site. Exposed subjects showed significantly higher levels of lead and cadmium in blood and urine than the controls. Excessive production of reactive oxygen species induced by these metals in exposed subjects conducted to a decrease in antioxidant defense system (GPx, Selenium, GSH) and an increase in lipid peroxidation (MDA). Moreover, changes in markers of nephrotoxicity (high urinary concentrations of total protein, RBP and CC16, as well as GSTα and LDH increased activities) suggested the occurrence of discrete and early signs of impaired renal function for the discharge neighboring population. |
| Databáze: | OpenAIRE |
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