First description of a clinical glutamine-dependent Escherichia coli with a missense mutation in the glnA

Autor:	Takehisa Matsumoto, Suguru Hiramoto, Takahiko Niwa, Hiroki Machida, Chiaki Suto, Miki Takahashi
Rok vydání:	2022
Předmět:	Microbiology (medical) Infectious Diseases Anti-Infective Agents Glutamate-Ammonia Ligase Glutamine Escherichia coli Mutation Missense Humans Pharmacology (medical) Escherichia coli Infections
Zdroj:	Journal of Infection and Chemotherapy. 28:1513-1518
ISSN:	1341-321X
Popis:	Small-colony variants (SCVs) of bacteria are subpopulations with a small colony size, low growth rate, and atypical colony morphology. The purpose of this study was to comprehensively elucidate the characteristics and underlying mechanism of the development of a glutamine-dependent SCV of E. coli, GU-92The GU-92The colony of the GU-92To the best of our knowledge, this is the first clinical isolation of a glutamine-dependent E. coli SCV from a patient blood culture. Our data showed that glnA was important for the growth of E. coli in Mueller-Hinton II medium, which also required the presence of glutamine when performing antimicrobial susceptibility testing for glutamine-dependent SCV strains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfc6e644b446b340a4f875f4187f665 https://doi.org/10.1016/j.jiac.2022.07.022 Zobrazit plný text záznamu Full Text from ScienceDirect