Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris
| Autor: | Gábor Tax, C. Diószegi, Márta Széll, Lajos Kemény, Andrea Koreck, Kornélia Kis, D. G. Teodorescu-Brinzeu, Kornélia Szabó, Krisztina Szegedi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Immunology Single-nucleotide polymorphism Minisatellite Repeats Biology Polymorphism Single Nucleotide Biochemistry Pathogenesis Gene Frequency Interleukin-1alpha Acne Vulgaris Genotype Genetics medicine Humans Immunology and Allergy SNP Genetic Predisposition to Disease Allele Alleles Acne Retrospective Studies General Medicine medicine.disease Interleukin 1 Receptor Antagonist Protein Variable number tandem repeat IL1A Case-Control Studies Female |
| Zdroj: | Tissue Antigens. 76:411-415 |
| ISSN: | 0001-2815 |
| DOI: | 10.1111/j.1399-0039.2010.01530.x |
| Popis: | Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne. |
| Databáze: | OpenAIRE |
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