Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography

Autor: James C. Moon, Gorka Bastarrika, Paul Scully, Thomas A. Treibel
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Gadolinium DTPA
medicine.medical_specialty
Cardiac PET
CT
and MRI (F Pugliese and SE Petersen
Section Editors)
Myocardial Infarction
Contrast Media
Computed tomography
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Endomyocardial biopsy
03 medical and health sciences
0302 clinical medicine
Tissue characterization
Fibrosis
Extracellular fluid
Medicine
Humans
Heart Failure
medicine.diagnostic_test
business.industry
Surrogate endpoint
Myocardium
Magnetic resonance imaging
Heart
Cardiomyopathy
Hypertrophic
medicine.disease
Magnetic Resonance Imaging
Extracellular Matrix
Diffuse fibrosis
cardiovascular system
Myocardial fibrosis
Cardiovascular magnetic resonance
Radiology
Cardiology and Cardiovascular Medicine
business
Tomography
X-Ray Computed
Extracellular volume
Zdroj: Current Cardiology Reports
ISSN: 1534-3170
1523-3782
Popis: Purpose of review This review article discusses the evolution of extracellular volume (ECV) quantification using both cardiovascular magnetic resonance (CMR) and computed tomography (CT). Recent findings Visualizing diffuse myocardial fibrosis is challenging and until recently, was restricted to the domain of the pathologist. CMR and CT both use extravascular, extracellular contrast agents, permitting ECV measurement. The evidence base around ECV quantification by CMR is growing rapidly and just starting in CT. In conditions with high ECV (amyloid, oedema and fibrosis), this technique is already being used clinically and as a surrogate endpoint. Non-invasive diffuse fibrosis quantification is also generating new biological insights into key cardiac diseases. Summary CMR and CT can estimate ECV and in turn diffuse myocardial fibrosis, obviating the need for invasive endomyocardial biopsy. CT is an attractive alternative to CMR particularly in those individuals with contraindications to the latter. Further studies are needed, particularly in CT.
Databáze: OpenAIRE
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