Plasma kynurenine and related measures in tic disorder patients
| Autor: | George M. Anderson, Ruud B. Minderaa, Cees G. M. Kallenberg, Pieter W. Troost, Pieter J. Hoekstra |
|---|---|
| Přispěvatelé: | Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Tic disorder DIFFERENTIATE PANDAS BLOOD SEROTONIN Hydrocortisone tic disorders Neurological disorder medicine.disease_cause chemistry.chemical_compound Developmental and Educational Psychology Child Indoleamine 2 3-dioxygenase STREPTOCOCCAL INFECTIONS Neopterin General Medicine Middle Aged SYDENHAMS CHOREA Psychiatry and Mental health 3-dioxygenase Child Preschool Female Psychology TOURETTES-SYNDROME Glucocorticoid medicine.drug Adult congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adolescent indoleamine 2 3-dioxygenase cortisol CEREBROSPINAL-FLUID Internal medicine mental disorders medicine Humans tryptophan SERUM AUTOANTIBODIES NEOPTERIN CONCENTRATIONS OBSESSIVE-COMPULSIVE DISORDER Immune dysregulation PEDIATRIC POPULATION medicine.disease nervous system diseases kynurenine body regions Endocrinology chemistry neopterin Case-Control Studies Pediatrics Perinatology and Child Health Immunology indoleamine 2 human activities Kynurenine |
| Zdroj: | European Child & Adolescent Psychiatry, 16(Suppl. 1), 71-77. SPRINGER |
| ISSN: | 1435-165X 1018-8827 |
| DOI: | 10.1007/s00787-007-1009-1 |
| Popis: | Objective Increased plasma kynurenine has been reported in tic disorder patients, and this observation has been suggested to be indicative of immune dysregulation. In the present study, we examined plasma levels of kynurenine and related molecules in a group of tic disorder patients. Methods Plasma concentrations of tryptophan, kynurenine, cortisol, and neopterin were determined in Dutch tic disorder patients (N = 59), and healthy volunteers (N = 32). Group means were compared and age-controlled intra-individual correlations between tic severity and plasma levels of these molecules were examined. Results No significant differences were found between patient and control groups in plasma levels of tryptophan, kynurenine, and cortisol concentrations, nor in the kynurenine/tryptophan ratio. However, neopterin was significantly (p = 0.035) higher in patients (mean = 5.13 nmol/1) than in controls (mean = 3.30 nmol/1). Plasma levels of these molecules did not correlate with tic severity, with the exception of tryptophan (r = -0.289, p = 0.049). In patients, plasma neopterin correlated with kynurenine (r = 0.438, P = 0.002); in healthy subjects, tryptophan correlated with kynurenine (r = 0.670, p |
| Databáze: | OpenAIRE |
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