PPARs: Protectors or Opponents of Myocardial Function?
| Autor: | Melissa Lieu, Christine J. Pol, Konstantinos Drosatos |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cardiac function curve
Peroxisome proliferator-activated receptor Review Article Disease 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Drug Discovery Medicine Pharmacology (medical) Receptor lcsh:QH301-705.5 030304 developmental biology chemistry.chemical_classification 0303 health sciences business.industry medicine.disease 3. Good health Review article lcsh:Biology (General) chemistry Nuclear receptor Heart failure business |
| Zdroj: | PPAR Research, Vol 2015 (2015) PPAR Research |
| ISSN: | 1687-4765 1687-4757 |
| Popis: | Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family. There are three PPAR isoforms: PPARα, PPARγ, and PPARδ. They can be activated by endogenous ligands, such as fatty acids, as well as by pharmacologic agents. Activators of PPARs are used for treating several metabolic complications, such as diabetes and hyperlipidemia that are directly or indirectly associated with HF. However, some of these drugs have adverse effects that compromise cardiac function. This review article aims to summarize the current basic and clinical research findings of the beneficial or detrimental effects of PPAR biology on myocardial function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|