Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children

Autor: Giorgia Bucciol, Isabelle Meyts, Laurent Abel, Salah Al-Muhsen, Alessandro Aiuti, Fahd Al-Mulla, Evangelos Andreakos, Novelli Antonio, Andrés A. Arias, Sophie Trouillet-Assant, Alexandre Belot, Catherine M. Biggs, Ahmed A. Bousfiha, Alex Bolze, Alessandro Borghesi, Petter Brodin, John Christodoulou, Aurélie Cobat, Antonio Condino-Neto, Stefan Constantinescu, Clifton L. Dalgard, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Filomeen Haerynck, Rabih Halwani, Elena W.Y. Hsieh, Yuval Itan, Kai Kisand, Yu-Lung Lau, Davood Mansouri, Trine H. Mogensen, Lisa F.P. Ng, Luigi D. Notarangelo, Giuseppe Novelli, Satoshi Okada, Tayfun Ozcelik, Rebeca Perez de Diego, Carolina Prando, Aurora Pujol, Lluis Quintana-Murci, Laurent Renia, Igor Resnick, Lucie Roussel, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Mohammed Shahrooei, Pere Soler-Palacín, András N. Spaan, Ivan Tancevski, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Pierre Tiberghien, Jordi Perez Tur, Stuart E. Turvey, Furkan Uddin, Mohammed J. Uddin, Mateus Vidigal, Donald C. Vinh, Mayana Zatz, Keisuke Okamoto, David S. Perlin, Graziano Pesole, Christian Thorball, Diederik van de Beek, Roger Colobran, Joost Wauters, Shen-Ying Zhang, Qian Zhang, Helen C. Su, Jean-Laurent Casanova
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of allergy and clinical immunology. 151(4):832-840
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2023.02.003
Popis: Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019 (COVID-19) pandemic, global sequencing efforts have led in the field of inborn errors of immunity, and inspired particularly by previous research on life-threatening influenza, they have revealed that known and novel inborn errors affecting type I interferon immunity underlie critical COVID-19 in up to 5% of cases. In addition, neutralizing autoantibodies against type I interferons have been identified in up to 20% of patients with critical COVID-19 who are older than 80 years and 20% of fatal cases, with a higher prevalence in men and individuals older than 70 years. Also, inborn errors impairing regulation of type I interferon responses and RNA degradation have been found as causes of multisystem inflammatory syndrome in children, a life-threatening hyperinflammatory condition complicating otherwise mild initial SARS-CoV-2 infection in children and young adults. Better understanding of these immunologic mechanisms can aid in designing treatments for severe COVID-19, multisystem inflammatory syndrome in children, long COVID, and neuro-COVID.
Databáze: OpenAIRE
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