Concentrations in serum and distribution in tissue of free and liposomal amphotericin B in rats during continuous intralipid infusion
| Autor: | Gabriel Lopez-Berestein, V B Grossie, Kishor M. Wasan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Fat Emulsions Intravenous medicine.medical_specialty medicine.drug_class Antibiotics Spleen Pharmacology chemistry.chemical_compound Pharmacokinetics Amphotericin B medicine Animals Distribution (pharmacology) Drug Interactions Tissue Distribution Pharmacology (medical) Infusions Intravenous Drug Carriers Kidney Lung Dose-Response Relationship Drug Cholesterol business.industry Rats Inbred F344 Rats Surgery Infectious Diseases medicine.anatomical_structure chemistry Injections Intravenous Liposomes business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 38:2224-2226 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.38.9.2224 |
| Popis: | The influences of Intralipid (IL) and 0.45% normal-saline infusions on the concentration in serum and distribution in tissue of amphotericin B (AmpB) and liposomal amphotericin B (L-AmpB) in rats were compared. In animals receiving a continuous IL infusion, concentrations of AmpB in kidneys and lungs were significantly higher, but the concentration of AmpB in serum was significantly lower in animals administered AmpB versus those given L-AmpB. In animals receiving a continuous normal-saline infusion concentrations of AmpB in kidneys and the spleen were significantly higher, but the concentration of AmpB in serum was significantly lower in animals administered AmpB versus those given L-AmpB. These results suggest that the increased total serum cholesterol and high-density lipoprotein cholesterol during the IL infusion decreased the clearance of AmpB from the bloodstream and decreased the L-AmpB concentration in the kidney and lung. |
| Databáze: | OpenAIRE |
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