CD8(+) granulomatous cutaneous T-cell lymphoma: a potential association with immunodeficiency
| Autor: | Alistair Robson, Bryan Gammon, Janyana M.D. Deonizio, Joan Guitart, Lisa M. Arkin |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Dermatology CD8-Positive T-Lymphocytes Immunocompromised Host Mycosis Fungoides Agammaglobulinemia hemic and lymphatic diseases Biopsy medicine Humans Medical history Immunodeficiency Aged Retrospective Studies Mycosis fungoides Granuloma medicine.diagnostic_test business.industry Common variable immunodeficiency Cutaneous T-cell lymphoma Genetic Diseases X-Linked Middle Aged medicine.disease Lymphoma Lymphoma T-Cell Cutaneous Common Variable Immunodeficiency Disease Progression business CD8 |
| Zdroj: | Journal of the American Academy of Dermatology. 71(3) |
| ISSN: | 1097-6787 |
| Popis: | Background Granulomatous cutaneous T-cell lymphoma (G-CTCL) is a rarely encountered entity. Most G-CTCL is CD4 + , with granulomatous mycosis fungoides representing the vast majority of cases. Because of the rarity of CD8 + G-CTCL, there is a paucity of data regarding the clinicopathologic features and expected course. Objective To describe the clinical and histopathologic features of G-CTCL. Methods This is a retrospective review of collected cases. Results We present 4 cases of CD8 + G-CTCL. Patients presented with papules and nodules on the trunk and extremities without antecedent patch or plaque disease. In all cases, biopsy specimens were obtained, and these revealed a dense granulomatous infiltrate accompanied by an atypical lymphoid infiltrate of CD8 + T cells. T-cell clonality studies were positive in 3 of 4 cases. Staging was negative for nodal involvement, but lung granulomas were seen in all cases. In all 4 cases, the patient's medical history was significant for immunodeficiency, either primary or iatrogenic. All 4 patients had slowly progressive disease. Limitations This is a small retrospective case series. Conclusions CD8 + G-CTCL appears to be associated with immunodeficiency. The finding of a CD8 + G-CTCL should prompt an evaluation for underlying immunodeficiency. Additional studies are required to validate these conclusions. |
| Databáze: | OpenAIRE |
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