Proton Pump Inhibitors Intake and Iron and Vitamin B12 Status: A Prospective Comparative Study with a Follow up of 12 Months
| Autor: | Elton Bahtiri, Rexhep Hoxha, Kujtim Thaçi, Ismet H. Bajraktari, Shemsedin Sadiku, Mentor Sopjani, Hasime Qorraj-Bytyqi, Shpetim Thaçi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Homocysteine Iron lcsh:Medicine Iron: Ferritin Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hypovitaminosis Basic Science Internal medicine medicine Vitamin B12 Pharmacology Ferritin Hematology medicine.diagnostic_test biology business.industry PPIs lcsh:R Antisecretory agents General Medicine chemistry 030220 oncology & carcinogenesis Baseline characteristics Serum iron Mann–Whitney U test biology.protein Medicine 030211 gastroenterology & hepatology business |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences; Vol 6 No 3 (2018): Mar 15 (OAMJMS); 442-446 Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences; Vol 6, No 3 (2018): Mar 15 (OAMJMS); 442-446 Open Access Macedonian Journal of Medical Sciences, Vol 6, Iss 3, Pp 442-446 (2018) |
| ISSN: | 1857-9655 |
| Popis: | BACKGROUND: Proton pump inhibitors (PPIs) represent the most widely prescribed antisecretory agents, but their prolonged use, may influence iron and vitamin B12 status, which could have important implications for clinical practice.AIM: We undertook this study aiming to investigate the association between PPIs use for 12 months and potential changes in iron and vitamin B12 status, as well as whether this potential association varies among four specific PPI drugs used in the study.METHODS: A total of 250 adult subjects were recruited into this study, of which 200 subjects were PPIs users while 50 subjects belonged to the control group. Serum iron, ferritin, vitamin B12, and homocysteine (Hcy) levels were measured before the start of the study and after 12 months. Mann - Whitney U test and Kruskal - Wallis test was used to compare the baseline characteristics of the study groups, while Wilcoxon test was used to analyse post - pre differences.RESULTS: Statistical analysis showed significant changes within PPIs group and specific PPIs subgroups between the two-time points in serum ferritin and vitamin B12 levels, respectively, while no significant changes in serum iron and homocysteine levels were shown. However, subsequent diagnosis of hypoferremia and hypovitaminosis B12 in the whole study sample at 12 months was established in only 3.8% and 2.9% of the subjects, respectively.CONCLUSION: PPIs use for 12 months did not result in clinically significant iron and/or vitamin B12 deficiency; thus, these findings argue routine screening under normal circumstances, although monitoring in elderly and malnourished may be of precious value. |
| Databáze: | OpenAIRE |
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