Dysregulations of long non-coding RNAs – The emerging 'lnc' in environmental carcinogenesis
| Autor: | Po-Shun Wang, Zhishan Wang, Chengfeng Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Carcinogenesis Computational biology Biology Article Metastasis 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Humans Epigenetics Carcinogen Environmental Carcinogen Cancer Environmental Exposure medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Environmental Carcinogenesis Carcinogens Metal Carcinogenesis RNA Long Noncoding Cancer Etiology |
| Zdroj: | Semin Cancer Biol |
| Popis: | Long non-coding RNAs (lncRNAs) refer to a class of RNA molecules that are more than 200 nucleotides in length and usually lack protein-coding capacity. LncRNAs play important roles in regulating gene expression as well as many aspects of normal physiological processes. Dysregulations of lncRNA expressions and functions are considered to be critically involved in the development and progression of many diseases especially cancer. The lncRNA research in the field of cancer biology over the past decade reveals that a large number of lncRNAs are dysregulated in various types of cancer and that dysregulated lncRNAs may play important roles in cancer initiation, metastasis and therapeutic responses. Metal carcinogens and other common environmental carcinogens such as polycyclic aromatic hydrocarbons, fine particular matters, cigarette smoke, ultraviolet and ionizing radiation are important cancer etiology factors. However, the mechanisms of how metal carcinogens and other common environmental carcinogen exposures initiate cancer and promote cancer progression remain largely unknown. Accumulating evidence show that exposure to metal carcinogens and other common environmental carcinogens dysregulate lncRNA expression in various model systems, which may offer novel mechanistic insights for environmental carcinogenesis. This review will first provide a brief introduction about lncRNA biology and the mechanisms of lncRNA functions, followed by summarizing and discussing recent studies about lncRNA dysregulation by metal carcinogen and other common environment carcinogen exposures and the potential roles of dysregulated lncRNAs in environmental carcinogenesis. A perspective for future studies in this emerging and important field is also presented. |
| Databáze: | OpenAIRE |
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