AllergoOncology - the impact of allergy in oncology: EAACI position paper
| Autor: | Rodolfo Bianchini, Manuel L. Penichet, Luca Vangelista, Elisa Agnese Nigro, Josef Singer, Eva Untersmayr, Heather J. Bax, Antonio G. Siccardi, Michelle C. Turner, T. R. Daniels-Wells, Francesca Levi-Schaffer, Mariana Castells, Diana Mechtcheriakova, Panagiotis Karagiannis, Christopher Corrigan, Frank A. Redegeld, S. Gatault, Debra H. Josephs, David Dombrowicz, Louise Saul, Erika Jensen-Jarolim, Sophia N. Karagiannis, Y. Mekori, Felicitas Mungenast, James Spicer, Judit Fazekas, Edda Fiebiger, Hannah J. Gould, Anastasia Meshcheryakova, Monique Capron, Jozef Janda, Edzard Spillner |
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| Rok vydání: | 2017 |
| Předmět: |
AllergoOncology
0301 basic medicine Allergy Immunology Inflammation Immunoglobulin E medicine.disease_cause Clinical oncology Antibodies Article Atopy 03 medical and health sciences Th2 Cells Immune system Neoplasms Hypersensitivity medicine Humans Immunology and Allergy Biologics desensitization Immunologic Surveillance Cancer Chemotherapeutic IgG4 Tumor biology Effector business.industry medicine.disease 3. Good health 030104 developmental biology Allergic response biology.protein Immunotherapy IgE medicine.symptom Antibody business |
| Zdroj: | Jensen-Jarolim, E, Bax, H J, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrowicz, D, Daniels-Wells, T R, Fazekas, J, Fiebiger, E, Gatault, S, Gould, H J, Janda, J, Josephs, D H, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, E A, Penichet, M L, Redegeld, F, Saul, L, Singer, J, Spicer, J F, Siccardi, A G, Spillner, E, Turner, M C, Untersmayr, E, Vangelista, L & Karagiannis, S N 2017, ' AllergoOncology-the impact of allergy in oncology : EAACI position paper ', Allergy, vol. 72, no. 6, pp. 866-887 . https://doi.org/10.1111/all.13119 Jensen-Jarolim, E, Bax, HJ, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrovicz, D, Daniels-Wells, HR, Fazekas, J, Fiebiger, E, Gatault, S, Gould, H, Janda, J, Josephs, DH, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, EA, Penichet, M F, Redegeld, F, Saul, L, Singer, J, Spicer, JF, Siccardi, AG, Spillner, E, Turner, MC, Untersmayr, E, Vangelista, L & Karagiannis, S N 2017, ' AllergoOncology-the Impact of Allergy in Oncology. EAACI Position Paper. ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 72, no. 6, pp. 866-887 . https://doi.org/10.1111/all.13119 |
| ISSN: | 0105-4538 |
| Popis: | Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment. |
| Databáze: | OpenAIRE |
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