Probe-hosted large area silicon photomultiplier and high-throughput timing electronics for enhanced performance time-domain functional near-infrared spectroscopy
Autor: | Felix Koberling, Davide Contini, Antonio Pifferi, Edoardo Ferocino, A. Dalla Mora, Alessandro Torricelli, Anurag Behera, L. Di Sieno, Benedikt Krämer, Sumeet Rohilla |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Spectrometer
Computer science business.industry Near-infrared spectroscopy Detector 01 natural sciences Article Atomic and Molecular Physics and Optics 010309 optics 03 medical and health sciences 0302 clinical medicine Silicon photomultiplier 0103 physical sciences Optoelectronics Functional near-infrared spectroscopy Time domain Electronics business Throughput (business) 030217 neurology & neurosurgery Biotechnology |
Zdroj: | Biomed Opt Express Biomedical Optics Express |
Popis: | Two main bottlenecks prevent time-domain diffuse optics instruments to reach their maximum performances, namely the limited light harvesting capability of the detection chain and the bounded data throughput of the timing electronics. In this work, for the first time to our knowledge, we overcome both those limitations using a probe-hosted large area silicon photomultiplier detector coupled to high-throughput timing electronics. The system performances were assessed based on international protocols for diffuse optical imagers showing better figures with respect to a state-of-the-art device. As a first step towards applications, proof-of-principle in-vivo brain activation measurements demonstrated superior signal-to-noise ratio as compared to current technologies. |
Databáze: | OpenAIRE |
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