Experimental and simulation results on the effect of cortical bone mineralization in ultrasound axial transmission measurements: A model for fracture healing ultrasound monitoring
| Autor: | Maryline Talmant, Mathilde Granke, Christiano Bittencourt Machado, Frederic Padilla, Wagner Coelho de Albuquerque Pereira, Pascal Laugier |
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| Rok vydání: | 2011 |
| Předmět: |
Time Factors
Histology Materials science Physiology Endocrinology Diabetes and Metabolism Microscopy Acoustic Bone healing Models Biological Mineralization (biology) Calcification Physiologic Speed of sound Microscopy medicine Animals Computer Simulation Ultrasonics Femur Edetic Acid Fracture Healing business.industry Ultrasound Numerical Analysis Computer-Assisted Anatomy Demineralization medicine.anatomical_structure Calcium Cattle Cortical bone business Femoral Fractures Biomedical engineering |
| Zdroj: | Bone. 48:1202-1209 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2011.02.021 |
| Popis: | Ultrasound axial transmission (UAT), a technique using propagation of ultrasound waves along the cortex of cortical bones, has been proposed as a diagnostic technique for the evaluation of fracture healing. Quantitative ultrasound parameters have been reported to be sensitive to callus changes during the regeneration process. The aim of this work was to identify the specific effect of cortical bone mineralization on UAT measurements by means of numerical simulations and experiments using a reverse fracture healing approach. A cortical bovine femur sample was used, in which a 3mm fracture gap was drilled. A 3mm thick cortical bone slice, extracted from another location in the bone sample, was submitted to a progressive demineralization process with EDTA during 12 days. UAT measurements and simulations using a 1MHz probe were performed with the demineralized slice placed into the fracture gap to mimic different stages of mineralization during the healing process. The calcium loss of the slice due to the EDTA treatment was recorded everyday, and its temporal evolution could be modeled by an exponential law. A 50MHz scanning acoustic microscopy was also used to assess the mineralization degree of the bone slice at the end of the intervention. These data were used in the numerical simulations to derive a model of the time evolution of bone slice mechanical properties. From both the experiments and the simulations, a significant and progressive increase in the time of flight (TOF; p |
| Databáze: | OpenAIRE |
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