Breath-hold gadolinium-enhanced MR angiography of the major vessels at 1.0 T: dose-response findings and angiographic correlation
| Autor: | M. Oelerich, U L Rausch-Lentschig, M G Lentschig, G Laub, Peter Reimer, Thomas Allkemper |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Aortography Gadolinium media_common.quotation_subject Aortic Diseases chemistry.chemical_element Contrast Media Sensitivity and Specificity medicine.artery medicine Image Processing Computer-Assisted Contrast (vision) Humans Radiology Nuclear Medicine and imaging media_common Aged Aorta medicine.diagnostic_test Dose-Response Relationship Drug Vascular disease business.industry Mr angiography Magnetic resonance imaging Middle Aged medicine.disease chemistry Angiography Female Radiology business Nuclear medicine Pulmonary Ventilation Magnetic Resonance Angiography |
| Zdroj: | Radiology. 208(2) |
| ISSN: | 0033-8419 |
| Popis: | To find the appropriate contrast agent dose for gadolinium-enhanced magnetic resonance (MR) angiography by using individual measurement of contrast agent transit times in a randomized study.A total of 34 patients with disease of the aorta or its major branches or both were randomly assigned to receive a dose of 0.1, 0.2, or 0.3 mmol of gadopentetate dimeglumine per kilogram of body weight. Initially, contrast agent transit times were measured with use of a turbo fast-low-angle-shot sequence. Subsequently, a three-dimensional fast imaging with steady-state precession sequence (7.3-msec repetition time, 2.8-msec echo time) was used for breath-hold MR angiography. Gadopentetate dimeglumine was injected with an MR-compatible power injector. Efficacy was evaluated by measurement of vessel enhancement and by clinical correlation of MR angiograms with x-ray angiograms.Evaluation of contrast agent transit time was possible in all patients with the test doses, which provided contrast-enhanced MR angiograms of constant quality. Neither vessel enhancement nor diagnostic information was significantly different across the these study groups.The clinical gadolinium dose of 0.1 mmol/kg is sufficient for diagnostic assessment of the aorta and its major branches at contrast-enhanced MR angiography. High-dose studies appear not to be required for these large vessels. |
| Databáze: | OpenAIRE |
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