Sleep hypoventilation in hypercapnic chronic obstructive pulmonary disease: prevalence and associated factors
| Autor: | Ronald McEvoy, Peter Catcheside, E.R. Collins, S E Rochford, Ronald R. Grunstein, Fergal J O'Donoghue, E E Ellis, Robert J Pierce, Lesley Rowland |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Sleep Wake Disorders Pulmonary and Respiratory Medicine Polysomnography Severity of Illness Index Hypercapnia Pulmonary Disease Chronic Obstructive Risk Factors Sleep and breathing Prevalence medicine Humans Aged COPD Anthropometry medicine.diagnostic_test business.industry Respiratory disease Hypoventilation Middle Aged medicine.disease Circadian Rhythm Respiratory Function Tests Respiratory failure Anesthesia Arterial blood Female Blood Gas Analysis medicine.symptom business |
| Zdroj: | European Respiratory Journal. 21:977-984 |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | Sleep hypoventilation (SH) may be important in the development of hypercapnic respiratory failure in chronic obstructive pulmonary disease (COPD). The prevalence of SH, associated factors, and overnight changes in waking arterial blood gases (ABG), were assessed in 54 stable hypercapnic COPD patients without concomitant sleep apnoea or morbid obesity. Lung function assessment, anthropomorphic measurements, and polysomnography with ABG measurement before and after sleep were conducted in all patients. Transcutaneous carbon dioxide tension (Pt,CO2) was measured in sleep, using simultaneous arterial carbon dioxide tension (Pa,CO2) for in vivo calibration and to correct for drift in the sensor. Of the patients, 43% spent > or = 20% of sleep time with Pt,CO2 > 1.33 kPa (10 mmHg) above waking baseline. Severity of SH was best predicted by a combination of baseline Pa,CO2, body mass index and per cent rapid-eye movement (REM) sleep. REM-related hypoventilation correlated significantly with severity of inspiratory flow limitation in REM, and with apnoea/hypopnoea index. Pa,CO2 increased mean+/-SD 0.70+/-0.65 kPa (5.29+/-4.92 mmHg) from night to morning, and this change was highly significant. The change in Pa,CO2 was strongly correlated with severity of SH. Sleep hypoventilation is common in hypercapnic chronic obstructive pulmonary disease, and related to baseline arterial carbon dioxide tension, body mass index and indices of upper airway obstruction. Sleep hypoventilation is associated with significant increases in arterial carbon dioxide tension night-to-morning, and may contribute to long-term elevations in arterial carbon dioxide tension. |
| Databáze: | OpenAIRE |
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