Co‐Assembly between Fmoc Diphenylalanine and Diphenylalanine within a 3D Fibrous Viscous Network Confers Atypical Curvature and Branching
| Autor: | Guanghong Wei, Yiming Tang, Tom Guterman, Zohar A. Arnon, Yifei Yao, Priyadarshi Chakraborty, Ehud Gazit |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Nanostructure 010405 organic chemistry Microfluidics Peptide 02 engineering and technology General Medicine General Chemistry 021001 nanoscience & nanotechnology 010402 general chemistry Branching (polymer chemistry) 01 natural sciences Catalysis 0104 chemical sciences Supramolecular polymers chemistry.chemical_compound Molecular dynamics chemistry Biophysics Diphenylalanine 0210 nano-technology Peptide sequence |
| Zdroj: | Angewandte Chemie International Edition |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.202009488 |
| Popis: | Supramolecular polymer co-assembly is a useful approach to modulate peptide nanostructures. However, the co-assembly scenario where one of the peptide building blocks simultaneously forms a hydrogel is yet to be studied. Herein, we investigate the co-assembly formation of diphenylalanine (FF), and Fmoc-diphenylalanine (FmocFF) within the 3D network of FmocFF hydrogel. The overlapping peptide sequence between the two building blocks leads to their co-assembly within the gel state modulating the nature of the FF crystals. We observe the formation of branched microcrystalline aggregates with an atypical curvature, in contrast to the FF assemblies obtained from aqueous solution. Optical microscopy reveal the sigmoidal kinetic growth profile of these aggregates. Microfluidics and ToF-SIMS experiments exhibit the presence of co-assembled structures of FF and FmocFF in the crystalline aggregates. Molecular dynamics simulation was used to decipher the mechanism of co-assembly formation. |
| Databáze: | OpenAIRE |
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