Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine
| Autor: | Mark S. Jensen, Wenjie Li, Robert D. Larsen, Gary Javadi, Dongwei Cai, Dorian P. Nelson, R. Scott Hoerrner |
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| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Pyrimidine Base (chemistry) Aryl Organic Chemistry chemistry.chemical_element Regioselectivity General Medicine Biochemistry Combinatorial chemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry Palladium |
| Zdroj: | ChemInform. 35 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200416140 |
| Popis: | Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle. [reaction: see text] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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